Relating Numbers of Foodborne Pathogens to Human Illness: Slides
Food Safety Initiative Technical Workshop:
Relating Numbers of Foodborne Pathogens to Human Illness
Introduction | Program | Talks | Abstracts | Qs & As | Slides | Biographies
Tuesday, August
4, 1998
Atrium, Stamp
Student Union
University
of Maryland
College Park,
MD
Slides
Limitations
of Current Dose-Response Data and Models: Information Needs for Microbiological
Risk Assessors
Margaret Coleman
1. Dose-Response Relationships for Surrogate
Pathogens
2. Dose-Response Relationships for Surrogate
Pathogens
3. Dose-Response Relationships for Surrogate
Pathogens
4. Dose-Response Relationships for Surrogate
Pathogens
5. Dose-Response Relationships for Surrogate
Pathogens
6. Observed Data and Fitted Curves for Surrogate
Pathogens
7. Difficulties: Interpreting Data from Animal
Models
8. System of Equations to Simulate the Number
of Damaged Host Cells vs. Time
9. Theoretical Example for Three Alternative
Model Forms
10. Theoretical Example for Three Alternative
Model Forms
11. Linear vs. Non-Linear Behavior
12. Non-Threshold and Threshold Estimates of Risk
13. Disease Triangle
14. Family of Murine Dose-Response Relationships
15. Human Salmonellosis: "Average" for Healthy
Adults
16. Family of Derived Human Salmonellosis Models
17. Salmonellosis Age Dependency
18. Family of Derived Human Salmonellosis Models
19. Pathogen Variability
20. Salmonella Strain Variability: Most Susceptible
Population
Mechanisms
of Pathogenesis of Salmonellae: Linking in vitro, Animal and Human
Studies
James Slauch, PhD
1. Course of Infection
2. Peyer’s Patch
3. Salmonella Invading an Epithelial Cell
4. Type III Secretion System
5. Regulation of the Type III Secretion System
6. Phenotype Conferred by Mutations in Invasion
System
7. Salmonella-induced Filaments
8. Attenuated Mutants as Vaccine Strains: Mice
and Men
Correlating
Host Resistance and Susceptibility with Biomarkers from in vitro, ex vitro and Animal Models
H. Kirk Ziegler, PhD
1. Listeria on a Macrophage [SEM]
2. Microbial Gene Expression, Virulence Factors
and the Life-cycle of Listeria monocytogenes
3. T cells Binding to Infected Macrophage
4. Antigen Processing, Presentation and Recognition
5. Macrophage Response to Microbial Invasion
6. Science cover, 11 October 1996
7. Role of T cells and NK cells in Primary Resistance
to Listeria
8. Model of Peritoneal Cell Dynamics During Infection
9. Model of Systemic Cytokine Dynamics During
Infection
10. Peritoneal
T Cells From HKLM + IL-12 Immunized Mice Respond Specifically to Listerial
Antigens in vitro
11. Immunization
With HKLM + IL-12 Confers Protective Anti-Listerial Immunity
12. Immunization
with HKLM + IL-12 Confers Long-Lived Protective Immunity
13. Control
vs. Knock-out Mouse Strains
14. Protective
Immunity Conferred by Immunization with HKLM + IL-12 is Independent of
MHC class I Expression
15. Protective
Immunity Conferred by Immunization with HKLM + IL-12 is Dependent on MHC
class II Expression
16. Protective
Immunity Conferred by Immunization with HKLM + IL-12 is Dependent on IFN-g
Expression
17. Synthetic
Peptides of LLO Elicit Strong Listerial Antigen-Specific Responses when
Administered i.p. With IL-12
18. Synthetic
Peptides of LLO Elicit Strong Listerial Antigen-Specific Responses When
Administered i.p. With IL-12
19. Synthetic
Peptides of LLO Elicit Protective Listeria-Specific Responses When Administered
i.p. With IL-12
20. Immune
Response to Listeria
