Food and Color Additives Hazard Characterization

Format	Author(s)	Title / Description	Date added	Details
	National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health	Aspartame: Questions and Answers Web page giving background information on aspartame and providing data from the NTP studies. Publication Date: Friday, July 26, 2002	Aug 23, 2002
	European Stevia Center, Laboratory of Plant Physiology, Biology Department, Faculty of Sciences, Catholic University of Leuven	European Stevia Center Center that promotes and coordinates research related to Stevia, stevioside, and related compounds. The website includes information about Stevia and stevioside, their safety and toxicology, related literature, publications, and more. (more)	Jan 6, 2005
	Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, Food and Drug Administration	Guidance for Industry: Templates for Reporting Toxicology Data Templates for the submission of toxicology data in support of petitions and notifications for safe use of food and color additives. Includes templates for "1) Subchronic Toxicity Study in Rodents, 2) Subchronic Toxicity Study in Dogs, 3) Genetic Toxicity Study: in vitro Bacterial Reverse Mutation (Ames) Test, 4) Genetic Toxicity Study: in vitro Mouse Lymphoma Thymidine Kinase Gene Mutation Assay, 5) Genetic Toxicity Study: Mammalian Erythrocyte Micronucleus Test, 6)Genetic Toxicity Study: in vitro Mammalian Chromosomal Aberration Test, 7) Chronic Toxicity Study with an in utero phase, 8) Chronic (1 year) Dog Toxicity Study, and 9) Two-Generation Reproduction Toxicity Study." There is also an Experimental Study Calculation Guide. (more) Publication Month: April 2005	May 16, 2005
	Center for Food Safety and Applied Nutrition, Food and Drug Administration	Guidance for Industry: Summary Table of Recommended Toxicological Testing for Additives Used in Food Guidance document offering "recommendations for the minimum toxicity tests to be performed for safety evaluation of direct food additives and color additives used in food based on their levels of concern". (more) Deadline: Wednesday, June 7, 2006 Publication Month: June 2006	Jun 7, 2006
	Institute of Food Science and Technology	Olestra This document provides an overview of olestra, including its chemistry, physiology, legislation, gastrointestinal effects, effects on fat-soluble vitamins, and more. (more) Publication Date: Wednesday, June 23, 1999	Aug 9, 2002
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the AFC Panel Related to a 8th List of Substances for Food Contact Materials Opinion adopted on April 27, 2005 regarding the evaluation of N,N'-dicyclohexyl-2,6-naphthalene dicarboxamide and mono-n-dodecyltin tris(isooctyl mercaptoacetate) and di-n-dodecyltin bis(isooctyl mercaptoacetate) as food contact materials. Includes as an appendix "Definition of the SCF Lists". (more) Publication Date: Wednesday, June 15, 2005	Jun 22, 2005
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the AFC Panel Related to Epoxy Phenolic Novolac Resins (NOGE) Opinion adopted on October 6, 2005 regarding the safety of NOGE as a starting substance in heavy duty epoxy coatings in light of new in vivo mutagenicity studies. (more) Deadline: Tuesday, November 15, 2005 Publication Date: Tuesday, October 25, 2005	Nov 15, 2005
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the AFC Panel Related to Semicarbazide in Food Opinion adopted on June 21, 2005 regarding analytical aspects, mechanisms of formation, occurrence and exposure, and toxicity of semicarbazide in foods. Includes as an annex "The EFSA advice on baby foods from October 2003". (more) Publication Date: Thursday, June 30, 2005	Jul 6, 2005
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the AFC Panel to Review the Toxicology of a Number of Dyes Illegally Present in Food in the EU Opinion adopted on August 5, 2005 regarding reviews of toxicological data on Sudans I, II, III, and IV, Para Red, Rhodamine B, Orange II, and other dyes that could potentially appear illegally in foods. The full reviews are provided as annexes. (more) Deadline: Monday, September 19, 2005 Publication Date: Monday, September 12, 2005	Sep 19, 2005
	Health and Consumer Protection Directorate-General, European Commission	Opinion of the Scientific Committee on Food: Update on the Safety of Aspartame Report of the committee regarding recent data regarding aspartame. Concludes "there is no evidence to suggest that there is a need to revise the outcome of the earlier risk assessment or the ADI previously established for aspartame". (more) Publication Date: Tuesday, December 10, 2002	Feb 10, 2005
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a Request from the Commission Related to 2,2-bis(4-hydroxyphenyl)propane bis(2,3-epoxypropyl)ether (Bisphenol A diglycidyl ... Opinion adopted on July 13, 2004 regarding the carcinogenicity and genotoxicity of Bisphenol A diglycidyl ether (BADGE) used in epoxy resins and vinylic organosols in internal can coatings. A Tolerable Daily Intake is established for BADGE and its hydrolysis products. Includes as an annex "2,2- bis(4-hydroxyphenyl)propane bis(2,3-epoxypropyl)ether (Bisphenol A diglycidyl ether, BADGE) Evaluation of toxicology". (more) Publication Date: Monday, July 26, 2004	Aug 2, 2004
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on Hydrocyanic Acid in Flavourings and Other Food Ingredients with Flavouring Properties. (Question Number EFSA-Q-2003-145) Opinion adopted on October 7, 2004 regarding human health effects from dietary intake of hydrocyanic acid. Includes discussion of exposure, toxicity, and more. (more) Publication Date: Friday, November 19, 2004	Nov 22, 2004
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission Related to Para Hydroxybenzoates (E 214-219). (Question Number EFSA-Q-2004-063) Opinion adopted on July 13, 2004 regarding the safety of paraben (E 214-219) usage in foods. Includes discussion of new toxicologic studies and establishment of a full group ADI for the sum of methyl and ethyl p-hydroxybenzoic acid esters and their sodium salts. (more) Publication Date: Tuesday, September 28, 2004	Sep 29, 2004
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission Related to Pullalan PI-20 For Use as a New Food Additive (Question Number EFSA-Q-2003-138) Opinion adopted on July 13, 2004 regarding the use of pullulan in the production of capsules and coated tablets for dietary supplements and in breath-freshening edible films. Includes discussion of predicted exposure, toxicology, and more. (more) Publication Date: Wednesday, September 29, 2004	Sep 29, 2004
	Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission Related to Tertiary-Butylhydroquinone (TBHQ). (Question number EFSA-Q-2003-141) Opinion adopted on July 12, 2004 regarding the safety of TBHQ used in fats and oils for human consumption. Includes discussion of stability in food during heating and storage, dietary exposure, and toxicology, and an ADI is established. (more) Publication Date: Monday, October 11, 2004	Oct 14, 2004
	French Food Safety Agency	Opinion on a Possible Link Between the Exposition to Aspartame and the Incidence of Brain Tumours in Humans This report includes discussion of the toxicity of aspartame and the exposure of French consumers to aspartame. Also available in French. (more) Publication Date: Tuesday, May 7, 2002	Jul 30, 2002
	Institute of Food Science and Technology	Salt This document gives an overview of the health risks associated with salt intake. It includes the effects of dietary excess of salt, effects of salt on calcium absorption, sodium intake in the UK, recommended intake, salt content in manufactured foods, labelling issues, and more. (more) Publication Month: February 2003	Aug 9, 2002
	Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food, European Food Safety Authority	Statement on the Possibility of Allocating a Group-TDI for Certain Phthalates Statement expressed on June 28, 2005 regarding the possibility of allocating a group TDI for butylbenzylphthalate (BBP), dibutylphthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP). (more) Deadline: Friday, October 14, 2005 Publication Date: Tuesday, June 28, 2005	Oct 14, 2005
	Food and Agricultural Organization of the United Nations/World Health Organization	Summary of Evaluations Performed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA 1956-2001) (First through fifty-seventh meetings): Internet Edition Searchable collection of summaries of evaluations performed on the safety of additives, contaminants, and veterinary drug residues. (more) Publication Year: 2001	Aug 31, 2001
	National Toxicology Program, U.S. Department of Health and Human Services	Toxicology and Carcinogenesis Studies of Sodium Nitrite (CAS NO. 7632-00-0) Drinking Water Studies in F344/N Rats and B6C3F1 Mice Report on studies of the effects of different doses of sodium nitrite in drinking water consumed by rats and mice over 14-week or two-year time periods and of the genetic toxicity of sodium nitrite. (more) Publication Month: May 2001	Aug 14, 2002

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