General Chemical Hazards Hazard Characterization/Toxicology

Format	Author(s)	Title / Description	Date added	Details
	Environmental Defense	About the Chemicals: Chemical Profile Search Searchable collection of fact sheets for over 11,000 chemicals. The fact sheets compile data from many government and scientific sources. In most cases, links are provided to the original sources when available. (more)	Jan 14, 2004
	Food and Agriculture Organization of the United Nations/World Health Organization	Animal Feed Impact on Food Safety Report of a Joint FAO/WHO Expert Meeting on Animal Feed Impact on Food Safety which was held at FAO Headquarters in Rome from 8 to 12 October 2007. The meeting concluded that ensuring safe feed is an important component of efforts to reduce and prevent food safety hazards and indicated several potential measures to ensure safe feed. Agenda of the meeting, list of participants, experts' resumes and list of documents are included as appendices. The report is being translated in French and Spanish. Printed copies may be requested from: Daniela.Battaglia@fao.org. (more) Publication Year: 2008	Feb 26, 2008
	Annual Reviews	Annual Reviews of Pharmacology and Toxicology This annual publication features critical reviews of the most significant primary pharmacology and toxicology research of the year. (more)	Aug 15, 2002
	National Center for Environmental Assessment, Office of Research and Development, Environmental Protection Agency	Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment (External Review Draft 2005) Draft report on the evaluation and use of PBPK models in human health risk assessment. Appendices include "Algorithms for predicting chemical-specific parameters for PBPK models," "List of publications relevant to PBPK modeling of environmental chemicals and its use," and "Partition coefficients and metabolic rate constants for PBPK modeling of environmental." Comments are requested. The public comment period has been extended in 70 FR 48950. (more) Deadline: Friday, October 14, 2005 Publication Month: June 2005	Aug 17, 2005
	Springer Berlin Heidelberg/Deutsche Gesellschaft fur Experimentelle und Klinische Pharmakologie und Toxikologie/EUROTOX	Archives of Toxicology This monthly journal is the official journal of EUROTOX. Topics covered include toxicity of chemicals in humans and experimental animals, and other aspects of toxicology. (more)	Jun 15, 2002
	Association of Government Toxicologists	Association of Government Toxicologists Professional organization of government toxicologists. The website includes events, abstracts of talks from AGT meetings, links, and more. (more)	Sep 24, 2002
	National Center for Computational Toxicology, Office of Research and Development, Environmental Protection Agency	Bibliographic Information on EPA's Computational Toxicology Research Programs 2000-2004 Bibliography of publications related to EPA's computational toxicology research. Categories of publications include "Improve Linkages in the Source-to-Outcome Paradigm," "Provide Predictive Models for Hazard Identification," and "Enhance Quantitative Risk Assessment". (more) Deadline: Friday, February 17, 2006	Feb 17, 2006
	American Chemical Society	Chemical Research in Toxicology International journal that publishes information regarding the chemical basis of toxicological responses.	Aug 28, 2002
	Office of Pollution Prevention and Toxics, Environmental Protection Agency	Chemicals in the Environment: OPPT Chemical Fact Sheets These fact sheets for selected environmental chemicals describe exposure routes, production and consumption of products, effects of exposure (including dose-response information, toxicity, and carcinogenicity), regulation information, contact information, and more. (more)	Sep 3, 2002
	Risk Assessment Program, Toxicology and Risk Analysis Section, Life Sciences Division, Oak Ridge National Laboratory, Department of Energy	Chemical-Specific Factors Database of chemical-specific factors that can be used in dose calculations. The database may be searched by the chemical-specific factor, analytes, and CAS numbers. You may view the output in an onscreen table or may download a tab or comma delimited file. (more)	Aug 30, 2002
	Risk Assessment Program, Toxicology and Risk Analysis Section, Life Sciences Division, Oak Ridge National Laboratory, Department of Energy	Chemical-Specific Toxicity Values Database of chemical-specific toxicity values derived from the EPA's Integrated Risk Information System (IRIS), the Health Effects Assessment Summary Tables (HEAST), and other sources. You may retrieve data for oral, inhalation, or dermal pathways on reference dose, reference concentration, unit risk, and slope factor. You may also retrieve a variety of other chemical-specific factors, including beef transfer coefficient, fish bioaccumulation coefficient, and milk transfer coefficient. You can format the output as an onscreen table, a tab delimited file, or a comma delimited file. (more)	Aug 27, 2002
	Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment	Committee on Toxicity (COT) Advisory committee to the UK government regarding the toxicity of chemicals. The website includes publications, information on their meetings, and more. (more)	Nov 15, 2004
	Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (non-food)/Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment/Committee on Carcinogenicity of Chemicals in Food, Consumer Products and th	Committees on Toxicity, Mutagenicity and Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COT, COM, COC): Joint Statement on the Use of Toxicogenomics in Toxicology Statement regarding the use of toxicogenomics in toxicological risk assessment. Publication Month: December 2004	Jan 13, 2005
	Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment/Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment/Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environme	Committees on Toxicity, Mutagenicity and Carcinogenicity of Chemicals in Food, Consumer Products and the Environment: Joint Statement on a Symposium Held by the Three Committees on the Use of Genomics and Proteomics in Toxicology Statement describing discussion and conclusions from a symposium on the use of genomics and proteomics in toxicological risk assessment. (more) Event Date: Monday, October 8, 2001 Publication Date: Tuesday, July 16, 2002	Nov 11, 2004
	LHASA Limited, School of Chemistry, University of Leeds	DEREK For Windows Knowledge base expert system that can be used to predict toxicological hazards based on analysis of chemical structure. Includes information on structure-toxicity relationships and provides supporting examples and literature references. (more)	Jan 22, 2003
	Office of Water, Environmental Protection Agency	Drinking Water Standards and Health Advisories This page provides access to EPA's Drinking Water Standards and Health Advisories tables that give standards (MCLG, MCL), health advisories (RfD, DWEL, lifetime, and cancer risk, as well as one-day and ten-day values for a 10-kg child), and cancer group for chemicals. (more)	Jul 23, 2003
	Risk Assessment Program, Toxicology and Risk Analysis Section, Life Sciences Division, Oak Ridge National Laboratory, Department of Energy	Ecological Benchmarks Database of ecotoxicological screening benchmarks for surface water, sediment, and surface soil applicable to aquatic organisms, soil invertebrates, and terrestrial plants. (more)	Aug 30, 2002
	Advisory Forum, European Food Safety Authority	EFSA Advisory Forum Event Berlin: Abstracts and presentations from this public event on topics related to the risk assessment process. Presentations include "Future perspectives in risk assessment: Key challenges and opportunities"/Jouve, Jean-Louis; "Future perspectives on risk assessment: key challenges and opportunities"/Feron, Victor J.; "Future perspectives on risk assessment: key challenges and opportunities"/Silano, Vittorio; "UK review of risks and benefits of fish consumption"/Benford, Diane; "Position of the French Committee of AFSSA on a risk/benefit analysis of GMOs"/Schwartz, Maxime; "Risk-benefit assessment of micronutrients - folic acid"/Flynn, Albert; and "Risk-benefit evaluation lessons for risk management and communication"/Renn, Ortwin. (more) Event Dates: Monday, November 8, 2004 - Tuesday, November 9, 2004 Publication Date: Friday, November 12, 2004	Aug 6, 2004
	Risk Assessment Program, Toxicology and Risk Analysis Section, Life Sciences Division, Oak Ridge National Laboratory, Department of Energy	Established Regulatory Limits for Surface Water and Groundwater Databases of established chemical-specific regulatory limits for surface water and groundwater are available at the federal level as well as at the state level for Illinois, Kentucky, Ohio, South Carolina, Tennessee, and Washington. (more)	Aug 27, 2002
	ScienceDirect/Elsevier Science	Food and Chemical Toxicology This journal publishes articles on the toxic effects of chemicals in food, water, and other consumer products on both humans and animals. It also publishes many articles related to the risk analysis process. (more)	Jul 23, 2002
	Food Safety Department, World Health Organization	GEMS/Food Instructions for Electronic Submission of Data on Chemical Contaminants in Food This document provides an introduction to the GEMS/FOOD Programme and Contaminants Database and gives the protocols for electronic submission of data to this database. (more) Publication Month: January 2002	Aug 16, 2002
	Foureman, Gary L.; Kenyon, Elaina M.	Harmonization in Interspecies Extrapolation: Use of BW3/4 as Default Method in Derivation of the Oral RfD (External Review Draft) Draft report on the use of body weight scaling to the 3/4 power as a general default procedure for interspecies extrapolation for the purposes of deriving an oral reference dose when approaches using physiologically based toxicokinetic modeling or some chemical-specific information are not feasible. Appendices include "BW3/4 scaling vs BW1/1 - a comparison," "The Interspecies BW3/4 Oral Dosimetric Adjustment Factor (DAF) BWh-1/4/BWa-1/4," "The Oral DAF and Portal-of-entry Considerations," and "Hierarchy of approaches for interspecies extrapolation for inhalation dosimetry (from USEPA 1994)." The web page also provides access to the peer review charge questions for the report and to a review of related literature. (more) Deadline: Monday, April 17, 2006 Publication Month: February 2006	Feb 17, 2006
	Dybing, E., et al.	Hazard Characterisation of Chemicals in Food and Diet: Dose Response, Mechanisms and Extrapolation Issues This report discusses biologically-based hazard characterization. It addresses the main issues in hazard characterization, and it focuses on low molecular weight chemicals. Topics covered include modes of toxicological action, causes of underlying variability in toxic responses, dose-response considerations, species differences and interspecies extrapolation, and more. Purchase or subscription is required to access full text. (more) Publication Month: February 2002	Jul 23, 2002
	Barlow, S.M., et al.	Hazard Identification by Methods of Animal-Based Toxicology This paper discusses animal-based methods in toxicology and their contributions to hazard identification of chemical hazards in food. It discusses this topic as applied to the design of safety testing programs, the appropriateness of presently available toxicity testing methodologies for detecting chemical hazards in foods, and other issues. Purchase or subscription is required to access the full-text. (more) Publication Month: February 2002	Jul 23, 2002
	International Agency for Research on Cancer	IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans Series of publications of assessments of carcinogenic risks to humans of various substances and exposures. Summaries of the data reported and the evaluations are available for free online, or the monographs may be ordered for a fee. (more)	Jun 23, 2003
	Iyaniwura, Timothy T.	Individual and Subpopulation Variations in Response to Toxic Chemicals: Factors of Susceptibility Review of the influence of age, gender, pregnancy status, dietary/nutritional status, disease/health status, and toxicokinetics and toxicodynamics on individual susceptibility and subpopulation responses to toxic chemicals. (more) Publication Date: Thursday, July 1, 2004	Sep 13, 2004
	National Center for Environmental Assessment, Office of Research and Development, Environmental Protection Agency	Integrated Risk Information System (IRIS) Database of chronic non-cancer and cancer health hazard information for over 500 substances. Includes dose-response data. (more)	Aug 31, 2001
	Toxicology Excellence for Risk Assessment /Concurrent Technologies Corporation	International Toxicity Estimates for Risk (ITER) This database provides access to human health risk values of over 500 chemicals compiled from several international health organizations and independent groups. This database is now also available on the National Library of Medicine's TOXNET compilation of databases located at http://toxnet.nlm.nih.gov. (more)	Aug 31, 2001
	International Programme on Chemical Safety/Canadian Centre for Occupational Health and Safety	IPCS INCHEM This site provides access to documents related to chemical safety. It contains: Joint Expert Committee on Food Additives (JECFA) - Monographs and evaluations, Joint Meeting on Pesticide Residues (JMPR) - Monographs and evaluations, International Agency for Research on Cancer (IARC) - Summaries and Evaluations, Pesticide Data Sheets (PDSs), Poisons Information Monographs (PIMs), International Chemical Safety Cards (ICSCs), IPCS/CEC Evaluation of Antidotes Series, Concise International Chemical Assessment Document (CICADS), Environmental Health Criteria (EHC) monographs, Health and Safety Guides (HSGs), and Screening Information Data Set (SIDS) for High Production Volume Chemicals. (more)	Jan 27, 2004
		Mini-Monograph: Genomics and Risk Assessment Reports from ILSI's Health and Environmental Sciences Institute Committee on the Application of Genomics to Mechanism-Based Risk Assessment regarding the program, their efforts, and outcomes of their research. (more) Publication Month: March 2004	Jun 24, 2004
	Elsevier Science/ScienceDirect	Mutation Research - Genetic Toxicology and Environmental Mutagenesis This journal publishes articles on such topics as genetic toxicity testing of chemicals, monitoring and surveillance for genotoxic effects, new testing and monitoring methodologies, and more. Subscription or purchase is required to access full text. (more)	May 28, 2003
	Division of Specialized Information Services, National Library of Medicine, National Institutes of Health	NLM-Tox-Enviro-Health-L Announcements List Email list that announces updated SIS resources, services, or outreach related to toxicology and environmental health.	Nov 5, 2003
	National Toxicology Program, National Institutes of Health	NTP Reports This site gives access to many of the NTP Toxicology and Carcinogenesis Reports and NTP Toxicity Reports. Many abstracts and full text reports are available for free. Hard copies of some reports may be ordered for a charge. Report titles may be browsed by number or found by full text search. (more)	Aug 14, 2002
	Organisation for Economic Co-operation and Development	OECD Principles for the Validation, for Regulatory Purposes, of (Quantitative) Structure-Activity Relationship Models Principles to consider when evaluating a (quantitative) structure-activity relationship model for regulatory use. Deadline: Wednesday, December 14, 2005 Publication Month: November 2004	Dec 14, 2005
	Ruden, Christina	Principles and Practices of Health Risk Assessment under Current EU Regulations Article discussing the European Union risk assessment process for chemicals and related principles and issues. Case studies that compare risk assessments performed for trichloroethylene and acrylamide and associated expert and public consensus on each chemical's carcinogenicity are also presented. Access to the full text from this site may require subscription or purchase. (more) Deadline: Wednesday, February 15, 2006 Publication Month: February 2006	Feb 15, 2006
	National Toxicology Program, Public Health Service, U.S. Department of Health and Human Services	Report on Carcinogens Report on substances that are or may be human carcinogens. It includes carcinogenicity, exposure, and regulations by Federal agencies to limit exposures. It also includes a list of names and synonyms of known carcinogens and substances reasonably anticipated to be carcinogens, information on manufacturing processes, occupations, and exposure circumstances known to be carcinogens, a listing of substances removed from the report, and a listing of substances reviewed but not recommeded for listing in the report. (more)	Aug 14, 2002
	Society of Toxicologic Pathology	Society of Toxicologic Pathology Non-profit association that works to advance pathology related to chemically, environmentally, or pharmacologically induced changes. The website includes events, publications including Toxicologic Pathology, the International Harmonization of Rat Nomenclature, a bibliography of related publications, and more. (more)	Jan 26, 2004
	Society of Toxicology	Society of Toxicology Professional organization for those interested in the science and applications of toxicology. The website includes a directory of toxicology specialists, publications, courses, career information, links, and more. (more)	Nov 5, 2002
	Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment/Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment	Statement on Joint COC and COM Meeting 9 June 2005: Use of Target Organ Mutagenicity Data in Carcinogen Risk Assessment Statement on a meeting to discuss the use of target organ mutagenicity studies in carcinogen risk assessment. Deadline: Friday, January 6, 2006 Event Date: Thursday, June 9, 2005 Publication Month: October 2005	Jan 6, 2006
	Toxicology Excellence for Risk Assessment	TERA Staff Publications Citations to publications related to noncancer risk assessment, cancer risk assessment, chemical-specific assessment, exposure assessment, mixtures risk assessment, metabolism, mutagenicity, alternatives to animal testing, respiratory toxicology, physical hazards, information resources and risk assessment tools, databases, commentaries, and TERA reports. Links are provided to many of the documents. (more)	May 29, 2003
	Risk Assessment Program, Toxicology and Risk Analysis Section, Life Sciences Division, Oak Ridge National Laboratory, Department of Energy	Toxicity Metadata Database of toxicity metadata compiled from IRIS/HEAST/NCEA. You can search for information by noncarcinogenic and carcinogenic parameters, analytes, and CAS numbers. The results may be viewed in an onscreen table or downloaded in a tab or comma delimited file. (more)	Aug 30, 2002
	Risk Assessment Program, Toxicology and Risk Analysis Section, Life Sciences Division, Oak Ridge National Laboratory, Department of Energy	Toxicity Profiles Database of toxicity profiles based on information from the EPA's Integrated Risk Information Systm (IRIS) and Health Effects Assessment Summary Tables (HEAST) and other sources. The profiles are presented in three formats with varying depth of coverage and technical level of language. They may be used to find exposure pathways, carcinogenic and noncarcinogenic human health effects, and dose response information for the available chemicals. (more) Deadline: Tuesday, January 1, 1980	Aug 27, 2002
	Society of Toxicology	Toxicological Sciences This monthly journal publishes articles related to toxicological effects on humans or animals from a variety of substances. Abstracts may be viewed for free online, but full text requires a subscription. (more)	Nov 5, 2002
	Elsevier Science	Toxicology and Applied Pharmacology This journal, published twice a month, is an official journal of the Society of Toxicology. It publishes articles on the effects of substances on the tissue structure or function of humans or animals. Abstracts are available for free online, but a subscription is required to view the full text. (more)	Nov 5, 2002
	Toxicology Excellence for Risk Assessment	Toxicology Excellence for Risk Assessment: TERA Nonprofit organization that works for the use of toxicology data in risk assessment. The website includes resources for risk assessors, the International Toxicity Estimates for Risk (ITER) database, information on Verifiable Estimates for Risk Assessment (VERA) and related projects, publications listings, research project information, and more. (more)	May 29, 2003
	Biology Project, University of Arizona	Toxicology Problem Set Problem set and tutorial that teach the basic principles of toxicology. Publication Year: 1997	Aug 30, 2002
	Toxicology and Environmental Health Information Program, Specialized Information Services, National Library of Medicine, National Institutes of Health	TOXLINE Bibliographic database of toxicology literature, including documents on risk analysis, risk communication and risk perception. (more)	Aug 31, 2001
	Toxicology and Environmental Health Information Program, Specialized Information Services Division, National Library of Medicine, National Institutes of Health	TOXNET Bibliographic databases on toxicology, hazardous chemicals, and more.	May 1, 2002
	Chen, James J., et al.	Using Dose Addition to Estimate Cumulative Risks from Exposures to Multiple Chemicals This paper presents a procedure to estimate cumulative risk from multiple chemicals by using the dose-response function of the mixture through dose addition. This procedure is compared to the hazard index, point-of-departure index, and toxicity equivalence factor methods. Subscription is required to access the full text. (more) Publication Month: August 2001	Jun 13, 2003

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